Due to overuse and misuse of common antibiotics an increased development of resistant pathogens has been observed. Therefore, new antimicrobial materials that may prevent the usage of antibiotics in the first place have become of great interest. [1,2] One field of application is dental implantology. Since the body does not immediately form a fibrous connection between implant and gum tissue, pockets remain (fig. 1). [5] These areas are not accessible from the outside and biofilms start to form, thus postoperative infections are among the most common side effects regarding dental implants. By coating the titanium socket of said implants with polymers that exhibit antimicrobial properties, infections may be averted completely. [1,2] Guanidine and biguanide derivatives are long known to have antimicrobial activity. Due to their strong basic nature they are protonated in biological environment and the resulting cation acts as a bidentate ligand towards the negatively charged phospholipid membrane of the bacterial cell wall, potentially surpassing the antimicrobial activity of QAC based counterparts. [3,4] However, most guanidine and biguanide synthesis require very specific reactants combined with harsh reaction conditions such as high temperature which is not always compatible with other functional groups, especially vinyl groups. [3,4] The aim of this work is the design of different guanidine and biguanide based monomers that can potentially be copolymerized by means of RAFT polymerization with monomers containing phosphonic acid groups acting as molecular anchors, [1,2] thus enabling the grafting of the respective polymers directly onto the titanium socket of the dental implant.