Research on cancer and anticancer strategies has been conducted extensively over the last two decades, presenting novel approaches for effective targeted therapies. Lungs are considered an ideal route for therapeutics to enter the body, allowing for the delivery of local concentrations of active pharmaceuticals with a lower burden on the rest of the body. The delivery of the therapeutic via the lungs is promising, but several things should be considered. The scope of this project involves the synthesis and preparation of microgels incorporating smart nanogels for the pulmonary delivery of an anticancer drug to the lungs. The system will feature a targeting moiety for cancer cells and a stealth capability to enable the nanogel's incorporation into the deep lung. These formulations can be a solution for delivering drugs by increasing their size due to hydrophilicity, which helps avoid macrophages and better addresses the lung microenvironment. These nanogels can deliver the active compound, be biocompatible, and have good physicochemical properties. Adding responsiveness, such as pH, can give an extra property and transform the formulations from passive materials to active ones.