In nature, carrying out specific chemical reactions is often challenging due to the presence of numerous competing reactive groups and strong dilution. However, enzymes, as highly efficient biological catalysts, overcome this challenge by employing a proximity effect, where reactants are brought into close spatial arrangement within the active site, significantly accelerating reaction rates.
Inspired by this natural strategy, we present a supramolecular templating approach which enables to successfully carry out chemical transformation even under strong dilutions. For this purpose, we are utilizing a pyrene anchoring system and polymersomes as supramolecular template. In this design, reactive functional groups conjugated to the pyrene anchor are positioned in close proximity upon binding to the supramolecular template, creating a dynamic and localized reaction environment that enhances reaction efficiency. This work demonstrates how supramolecular strategies can mimic enzymatic functions to control reactivity in complex chemical systems.