(Co)polymers of N-isopropylacrylamide (NIPAM) are known for the thermosensitivity of their solutions in water. Such (co)polymers are non-toxic, therefore they are widely examined for drug delivery. Polylactides (PLAs) are also used in pharmacy and cell cultivation. Graft-copolymers of NIPAM and polyesters should have both thermosensitivity in water solutions, bioresorption and affinity for cells. Graft-copolymers were prepared via macromonomer approach. Lactide-based macromonomers were prepared by ROP gaining macromonomers with OH- or butyl- terminal groups (depending on synthetic strategy). According to 1H NMR spectrometry data both methacrylate- and acrylate-terminated macromonomers were copolymerized with NIPAM resulting in random copolymers. The lower critical solution temperature (LCST) of copolymers varies from 32 °C to 16 °C depending on macromonomer content (from 3 % to 17 % by weight, respectively). Interestingly, the end group (hydroxyl or butyl) of macromonomer units influences strongly on LCST of the copolymer: the presence of hydroxyl end group in a oligolactide chain reduced LCST to a lower extend (up to 20 °C) in comparison with hydrophobic butyl group (up to 16 °C).