Mechanophores are functional groups that undergo structural and property changes in the presence of mechanical stimuli (e.g., force). Inspired by nature, sacrificial bonds are weak bonds introduced in polymer backbones to provide dynamic behavior. Using mechanophores as sacrificial bonds in polymers can give them appealing properties such as self-healing, stimuli responsiveness, or higher toughness, but have also drawbacks as lower mechanical strength, and bad shape persistence. One possibility to limit the drawbacks could be to embed the sacrificial bonds in a macrocycle (acting as a tether), so that the parts of the bond would remain connected after breaking. Before implementing this concept in materials, it is important to understand the changes induced by this embedding on the sacrificial bond characteristics. Single-molecule force spectroscopy (SMFS) experiments are ideal for this, providing detailed information about bond breaking and even reformation. Here, we report the development of polymer chains containing such tethered sacrificial bonds suitable for SFMS experiments. The synthesis of systems based on two types of sacrificial mechanophore-based bonds, disulfide (-S-S-) and azo (-N=N-), is first described. Polymer chains are then grown on each side of these sacrificial tethered bonds by SET-LRP, made of a first flexible poly(methyl acrylate) block, and a "sticky" poly(glycidyl acrylate) block for adhesion on the substrate and on the AFM cantilever. Preliminary SMFS experiments were conducted on these polymers to understand how they respond to force and probe the signature of the sacrificial bond breaking.